Subject: IIDR eNews - November 10th, 2017

Issue 4 - November 10, 2017
This Month at IIDR 
CMCB Facility Highlight: The LECO 2D Gas Chromatography with Time-of-Flight Mass Spectrometer (GCxGC-TOFMS)

The GCxGC-TOFMS allows for optimal GC/MS performance, including advanced separation capabilities, powerful productivity enhancements and real-time self-monitoring instrument intelligence. The GCxGC-TOFMS is well suited for the separation and identification of analytes in complex samples, and uses two columns with different separation characteristics for the highly accurate separation of target compounds. With the GCxGC, hundreds to thousands of compounds can be detected in each run, increasing efficiency and productivity for samples that are too complex for conventional GC-MS systems. Visit the CMCB website to find out more about the GCxGC-MS, and over 60 other available equipment items. 

November ID / IIDR Combined Rounds: Probiotics, Diarrhea, and the Microbiome

Diarrhea remains the 2nd leading cause of death in children under the age of five. In this month’s ID/IIDR Combined Rounds, infectious disease investigators Dr. Michael Surette and Dr. Jeffrey Pernica discussed the effects of childhood diarrheal disease on the human microbiome and presented their current studies regarding the use of probiotics as an effective treatment for this devastating disease.
Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites

In their recent publication, IIDR members from Dr. Eric Brown's lab, in collaboration with Dr. Gerry Wright's lab screen actinomycete-derived extracts against nutrient transporter deletion strains to design a target-specific approach that increases the detection of antimetabolites from natural sources. Read more about how this unique solution can uncover the full potential of naturally derived antibiotics.

Magarvey Lab Describes Antibiotics & Specialized Metabolites from the Human Microbiota

A genetic analysis of sequenced human microbiota isolates reveal a huge pool of undiscovered antibiotics. Further, these specialized chemicals may be better at targeted human therapies than current broad spectrum antibiotics. Within Dr. Nathan Magarvey’s lab, IIDR students Walaa Mousa, Bilal Athar, and Nisanth Merwin catalogue and describe the totality of antibiotics discovered from human origin, and relays their role in disease.
Brown Lab Student Reviews the "Use of Genetic and Chemical Synthetic Lethality as Probes of Complexity in Bacterial Cell Systems"

Masters student Kristina Klobucar and her supervisor Dr. Eric Brown review the fields of genomics and chemical genomics to provide an overview of synthetic lethality screening and the power of these methods in studying biology and creating opportunities for antibacterial therapy.
IIDR Graduate Students Review the "Evolution of Salmonella - Host Cell Interactions through a Dynamic Bacterial Genome"

IIDR graduate students Bushra Ilyas and Caressa Tsai of Dr. Brian Coombes lab review their current understanding of how genome evolution has shaped the pathogenic interactions of Salmonella with their hosts during infection, and how high-throughput technologies and the advent of transcriptomics is advancing our understanding of the evolution of bacterial pathogenesis.

! World Antibiotic Awareness Week is next week, November 13th to the 19th. Visit and share the World Health Organization's campaign website here.

To IIDR members: if you have not already done so, please forward your lab meeting schedule to

The McMaster Bioinformatics Meet-Ups have been moved to the 4th Friday of each month. The next Meet-Up is November 24th at 4 pm at the Phoenix. All are welcome! To receive notices, please join us here.

! ID/ IIDR Combined Joint Rounds are presented on the first Wednesday of every month in MUMC HSC 4E20, and are open to all IIDR members and trainees. Click here to view the revised schedule.
Upcoming Events
! Wednesday, December 6th: ID / IIDR Combined Rounds
8:00 am - 9:00 pm

*View the ID / IIDR Combined Rounds Schedule here.
Wednesday, November 15th: Immunology and Infection Program (IIP) Seminar Series
Andrés Finzi "Exposing Env: Implications for Antibody Attack"
9:00 am - 10:00 am
MDCL- 3023

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