Subject: IIDR eNews - November 17th, 2017

Issue 5 - November 17, 2017
This Month at IIDR 

CMCB Facility Highlight: Dionex 350 Accelerated Solvent Extractor System

Accelerated solvent extraction (ASE) is a technique for extracting organic compounds from solid and semisolid samples with liquid solvents. ASE replaces Soxhlet, sonication, wrist shaking, and other extraction techniques, and uses less solvent and less time. The Dionex ASE automatically extracts up to 24 samples (1–100 grams each) simultaneously, and delivers up to three solvents automatically. The methods of the Dionex ASE Accelerated Solvent Extractor system can be used to extract many different types of molecules, including:
  • active ingredients, oils and organic acids, vitamins and antibiotics, detergents, drug delivery devices
  • contaminants, natural products, pesticides and herbicides in food, fat and lipid determination, herbal and dietary supplements
  • PAHs and semi-volatiles, PCBs, dioxans and furans, TPH, air sampling cartridges (XAD and PUFs), polybrominated flame retardants
  • paper and pulp, textiles and fibers
Visit the CMCB website to find out more about the Dionex 350 Accelerated Solvent Extractor (ASE) System, and over 60 other available equipment items.

World Antibiotic Awareness Week - IIDR’s “8 Antibiotic-Resistant Bacteria of Global Priority: IIDR Research, Discovery, & Antibiotic Development" Infographic

November 13th to the 19th is World Antibiotic Awareness Week. Throughout the week, the IIDR recognized its member’s research on various drug-resistant bacteria listed within the World Health Organization’s “Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis” article, which can be found here. Check out the complete infographic on the IIDR website.

View Infographic >

The Canadian Council of University Biology Chairs (CCUBC) Awards IIDR’s Stephanie Jones with Top ‘Graduate Research Prize’ for Most Innovative Refereed Journal Article in Canada

Stephanie Jones, a Vanier Scholar and senior PhD student in Dr. Marie Elliot’s lab, has just been awarded the top ‘Graduate Research Prize’ by the Canadian Council of University Biology Chairs (CCUBC). This award is given annually in recognition of publishing the best and most innovative refereed journal article based on graduate research this year in Canada. Read more about Stephanie's award below, and the full eLife article entitled "Streptomyces exploration is triggered by fungal interactions and volatile signalshere.

Read More >

Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.

Metallo-β-lactamases (MBLs) are notable enzymes that give rise to bacterial resistance against a broad range of beta-lactam antibiotics. Recently, Dr. Gerry Wright’s research group discovered an inhibitor of MBLs called aspergillomarasmine A (AMA) within the CMCB – a compound currently in it’s late stage preclinical development after being licensed to a Boston area pharmaceutical company. Within their most recent publication, the interaction of aspergillomarasmine with various MBLs is explored, revealing the mode of action of MBL inhibition.

Monocyte Activation is Elevated in Women with Knee-Osteoarthritis and Associated with Inflammation, BMI and Pain

In a recent publication, Dr. Dawn Bowdish and her PhD student Dessi Loukov found that monocytes were more activated and pro-inflammatory in women with osteoarthritis, and that elevated inflammation and body mass index were associated with increased monocyte activation. Further, the team found that women with osteoarthritis and more activated monocytes experienced worse pain than individuals with less activated monocytes. These findings highlight the importance of modulating inflammation and body mass to manage osteoarthritis and open up new avenues for therapeutic research.

Silent but deadly: IS200 Promotes Pathogenicity in Salmonella Typhimurium.

Bacterial insertion sequences were long presumed to be “junk” DNA. In a recent publication, this notion has been challenged with evidence that a dormant transposon encodes an overlooked regulatory RNA that is important for colonization of the mouse gastrointestinal tract by Salmonella Typhimurium. This study was led by Dr. Michael Ellis, a post-doc in the Brown lab who began this project during his doctoral work in the Haniford Lab, in collaboration with Brown lab PhD candidates Lindsey Carfrae and Craig MacNair.

! ID/ IIDR Combined Joint Rounds are presented on the first Wednesday of every month in MUMC HSC 4E20, and are open to all IIDR members and trainees. Click here to view the revised schedule.

!The IIDR Holiday Party is Friday, December 15th and the Collins Brewhouse in Dundas. Tickets are $10 and can be purchased in the IIDR Main Office - MDCL 2301. More information to follow.

! To IIDR members: if you have not already done so, please forward your lab meeting schedule to

The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) recently pre-announced the 6th Joint Call for transnational research projects “New Targets, Compounds and Tools”. Find out more about the 6th Joint Call here, and review the 5th JPIAMR results here.
Upcoming Events
! Wednesday, December 6th: ID / IIDR Combined Rounds
Dr Martha Fulford & Dr. Andrew Pawlowski
8:00 am - 9:00 pm
Wednesday, November 22nd: Work in Progress (WIP) Seminar Series
Yushi Yao "Long-lasting memory alveolar macrophages augment anti-bacterial host defense via accelerated neutrophil recruitment.”
Matt Woods "Characterizing the mechanism of the hormonal contraceptive-mediated increase of HIV-1 susceptibility in women.”
9:00 am - 10:00 am
Tuesday, November 28th: BBS Seminar Series
Dr. Larry Forney, University of Idaho - "Tracking woozles in our understanding of the human vaginal microbiome"
11:30 am - 12:30 pm
Wednesday, November 29: IIP Seminar Series
Stephanie Dewitte-Orr, Wilfred Laurier University
“Modulating innate antiviral immunity at the cellular level using nanotechnology”
9:00 am - 10:00 am
Thursday & Friday, December 14th - 15th: Data Carpentry Workshop
*Aimed at teaching biology and biomedical researchers the data management basics they need to make their data curation and analysis skills more efficient and reproducible.
9:00 am - 5:00 pm
Hamilton Hall, Room 102

*See the Website for more information
*Sign up on Eventbrite.

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