Subject: IIDR eNews - December 19th, 2017

Issue 9 - December 19th, 2017
This Week at the IIDR 

CMCB Facility Highlight: Bruker micrOTOF focus II

The Bruker micrOTOF offers sophisticated focus technology to provide a world-leading combination of mass accuracy, resolution, and sensitivity. Technical details include a resolution of >16.500 FWHM (typically 18.000 FWHM), a mass accuracy of <2ppm, and a mass range m/z 50-3000 Da. The MicrOTOF is paired with an Agilent HPLC equipped with a UV detector and binary pump with four solvent inlet lines (A1, A2, B1, B2). The micrOTOF focus II is the first choice for:
  • Molecular Formula Verification
  • De novo Formula Generation
  • Multi-Target Screening
  • Biomarker Discovery
  • Intact Protein Analysis.
Visit the CMCB website to find out more about our 60+ available equipment items.

Dr. John Whitney and students discover new family of antibacterial proteins used for bacterial warfare and make JBC’s “Editor’s Pick”

Competition between Gram-negative bacteria is mediated by the bacterial type VI secretion system (T6SS). The T6SS delivers antibacterial protein effectors between competing bacterial cells. However, the mode of action of the majority of effectors is unknown. In recent work published in the Journal of Biological Chemistry, Dr. John Whitney and his IIDR team identified two new families of effectors, and demonstrate that they kill bacteria by depleting cells of NAD+ and NADP+. Their important work highlights the essentiality of electron-carrying dinucleotides for bacterial viability, and was selected as a JBC “Editor’s pick” – deemed by the editorial board to be in this year's top 2 percent of published manuscripts in terms of significance and overall importance.

Dr. Wright talks about "living in a world of emerging microbial resistance"

The 2017 National Action Plan on Antimicrobial Resistance raises concern about drugmakers discarding antibiotic waste into the environment. When expelled antibiotics contaminate soil and water, microbes are given the opportunity to become drug-resistant, which can then result in antimicrobial resistance in human populations. In this article by science journalist Priyanka Pulla for the newspaper The Hindu, Dr. Gerry Wright comments on the growing presence of antibiotic resistance in the environment and it’s potential impacts on human health.

Read More >

Former IIDR student wins 2017 Council of Graduate Schools/ProQuest Distinguished Dissertation Award

Congratulations to Chad Johnston for receiving the 2017 Council of Graduate Schools/ProQuest Distinguished Dissertation Award. Dr. Johnston is a graduate of the McMaster PhD program in Biochemistry where he worked under the supervision of Dr. Nathan Magarvey. The CGS ProQuest prize is awarded annually to a PhD graduate deemed by the selection committee to have made significant contributions to their field of research, and C
had was selected among 57 other nominations from across Canada and the United States. In the 37 year history of this award, it has gone to a student from a Canadian University on only 3 occasions. This is the first time the award has gone to a student from McMaster. 
A huge thank you to everyone who came out on Friday to the 2017 IIDR Christmas Party! Thanks to Rebecca, Gina, and Bobbi-Anne for organizing the event, and to Null Hypothesis and friends for pulling off an excellent show.

We wish you all a Safe & Happy Holidays and look forward to seeing you again in the New Year!
! Planning for the next IIDR Trainee Day is underway. If you or someone you know is interested in being an IIDR Trainee Day 2018 Ambassador, please contact to sign up to our mailing list.

! We are currently in the process of collecting metrics for the 2017 year. A reminder to IIDR members to please forward your most recently updated CV to if you have not already done so.

! The Claesen lab has moved to the Lerner Research Institute at Cleveland Clinic, and are currently looking for motivated post-docs and students interested in unravelling molecular mechanisms in the human microbiome. Students interested in pursuing a PhD in the group can get in touch with Jan to discuss further ( The main graduate programs are through Lerner Molecular Medicine, Case Western Reserve University or Cleveland State University; more information can be found at
Upcoming Events
! Wednesday, January 10th: ID / IIDR Rounds
"A vaccine for tuberculosis: the final frontier"
Dr. Fiona Smaill & Dr. Zhou Xing
8:00 am - 9:00 am 
*ID / IIDR Rounds are open to all IIDR members and trainees. Click here to view the revised schedule.
! Wednesday, January 17th: Chemical Engineering Seminar Series
"CRISPR-Cas systems: from humble beginnings to today's headlines"
Prof. Sylvain Moineau, Université Laval
12:30 pm -1:20 pm
JHE 264
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